Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Parthenolide, Tanacetum parthenium
A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties.
MilliporeSigma™ Calbiochem™ BMP Inhibitor II, DMH1
The BMP Inhibitor II, DMH1, also referenced under CAS 1206711-16-1, controls the biological activity of BMP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Caspase-8 Inhibitor I, Cell-Permeable
The Caspase 8 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ Indirubin-3'-monoxime
A potent, reversible, and ATP-compatible inhibitor of GSK-3β (glycogen synthase kinase 3β), Cdk1 (cyclin-dependent kinase1) and Cdk5 (IC50 = 22 nM, 180 nM, and 100 nM, respectively).
MilliporeSigma™ Calbiochem™ MPTP Hydrochloride
A neurotoxin that is a precusor of MPP+ which is toxic to dopaminergic neurons and causes Parkinsonism
MilliporeSigma™ Calbiochem™ MAP Kinase Inhibitor Set I
The MAP Kinase Inhibitor Set I controls the biological activity of MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Akt Activator II, SC79
Akt Activator II, SC79, CAS 305834-79-1, is a cell-permeable compound that interacts with Akt PH domain PIP3 binding pocket and makes it more susceptible to phosphorylation by upstream Kinases.
MilliporeSigma™ Calbiochem™ Pifithrin-μ
Pifithrin-μ, CAS 64984-31-2, is a cell-permeable inhibitor of p53 interaction with Bcl-xL and Bcl-2. Inhibits p53 translocation to mitochondria without affecting the transactivation function of p53.
MilliporeSigma™ Calbiochem™ Insulin Expression Inducer, BRD7389
A cell-permeable naphthoquinolinedione compound that specifically induces insulin secretion in mouse αTC1-cells and promotes transdifferentiation to a β-cell-like status.
MilliporeSigma™ Calbiochem™ K-252c
A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (IC50 = 2.45 μM) and protein kinase A (IC50 = 25.7 μM).
MilliporeSigma™ Calbiochem™ Epoxomicin, Synthetic
Epoxomicin, Synthetic, CAS 134381-21-8, is a potent, specific, and irreversible inhibitor of chymotrypsin-like, trypsin-like, and peptidyl-glutamyl peptide hydrolyzing activities of the proteasome.
MilliporeSigma™ Calbiochem™ Tankyrase 1/2 Inhibitor VI, G007-LK
Tankyrase 1/2 Inhibitor VI, G007-LK, CAS 1380672-07-0, is a cell-permeable, potent and highly selective inhibitor of tankyrase (IC50 = 33 and 26nM for TNKS1 and TNKS2, respectively).
MilliporeSigma™ Calbiochem™ sFRP-1 Inhibitor
The sFRP-1 Inhibitor, also referenced under CAS 915754-88-0, controls the biological activity of sFRP-1. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
MilliporeSigma™ Calbiochem™ CTAP
A highly potent octapeptide that acts as a selective and brain penetrating bioavailableμ opioid receptor antagonist (IC50
MilliporeSigma™ Calbiochem™ RNA Polymerase I Inhibitor II, CX-5461
A cell-permeable, selective inhibitor of RNA polymerase I-mediated pre-rRNA transcription (IC50 = 142 nM in HCT-116 cells).